cephaeline dihydrochloride
Cephaeline hydrochloride
CAS: 5853-29-2
Molecular Formula: C28H39ClN2O4
cephaeline dihydrochloride - Names and Identifiers
cephaeline dihydrochloride - Physico-chemical Properties
| Molecular Formula | C28H39ClN2O4 |
| Molar Mass | 503.08 |
| Appearance | neat |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | White to yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ipecac, angola octagonal maple. |
| In vitro study | CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC 50 s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (K i ) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield K i s of 54 and 355 μM for CYP2D6 and CYP3A4, respectively. |
cephaeline dihydrochloride - Risk and Safety
| UN IDs | 1544 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in mouse: 74970ug/kg |
cephaeline dihydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.853 ml | 9.267 ml | 18.534 ml |
| 5 mM | 0.371 ml | 1.853 ml | 3.707 ml |
| 10 mM | 0.185 ml | 0.927 ml | 1.853 ml |
| 5 mM | 0.037 ml | 0.185 ml | 0.371 ml |
Last Update：2024-01-02 23:10:35
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View History
cephaeline dihydrochloride
[5-(benzenesulfonyl)-1-methyl-3-phenyl-1H-pyrazol-4-yl]methyl 3-chlorobenzoate
2-(4-甲基苯基)咪唑并[1,2-A]吡啶-3-胺
聚丙烯酰胺干粉(阴离子型)
咪唑吡啶-2-羧酸乙酯ETHYL IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE
1-[3-Dimethylamino propyl]-3-ethyl carbodiimide Hcl
Naphthol AS-BI-phosphate disodium
3-[2-(METHYLAMINO)-1,3-THIAZOL-5-YL]-3-OXOPROPANAL O-(4-CHLOROBENZYL)OXIME
(Val438)-LB24-AB (432-444) (huMan), (Val438)-Monophenol Monooxygenase (432-444) (huMan), (Val438)-SK29-AB (432-444) (huMan), (Val438)-TuMor Rejection Antigen AB (432-444) (huMan)
1-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethanone
[5-(benzenesulfonyl)-1-methyl-3-phenyl-1H-pyrazol-4-yl]methyl 3-chlorobenzoate
2-(4-甲基苯基)咪唑并[1,2-A]吡啶-3-胺
聚丙烯酰胺干粉(阴离子型)
咪唑吡啶-2-羧酸乙酯ETHYL IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE
1-[3-Dimethylamino propyl]-3-ethyl carbodiimide Hcl
Naphthol AS-BI-phosphate disodium
3-[2-(METHYLAMINO)-1,3-THIAZOL-5-YL]-3-OXOPROPANAL O-(4-CHLOROBENZYL)OXIME
(Val438)-LB24-AB (432-444) (huMan), (Val438)-Monophenol Monooxygenase (432-444) (huMan), (Val438)-SK29-AB (432-444) (huMan), (Val438)-TuMor Rejection Antigen AB (432-444) (huMan)
1-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethanone